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In vivo reports present anatomically selective neurochemical effects of modafinil on monoaminergic units (de Saint Hilaire et al 2001; Ferraro et al 2002), and, notably, even though modafinil raises TMN fos expression (Scammell et al 2000) and HAergic tone it is not able to exert this impact when administered specifically into the TMN (Ishizuka et

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